Klinik und Poliklinik für Psychiatrie und Psychotherapie
 Universitätsmedizin Leipzig

Dr. rer. nat. Tilman Hensch

Senior scientist
Telefon 0341-97 24 587
Telefax 0341-97 24 539
E-Mail tilman.hensch@medizin.uni-leipzig.de


  • Since 12/2008: Senior scientist, Neurobiology Research, Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig.
  • 2002-2008: Research associate, working group Neurogenetics and Individual Differences (Prof. Brocke), Institute of Clinical, Diagnostic and Differential Psychology, University of Technology - TU Dresden, Dresden.
  • 2000-2001: Research associate, working group Prof. Schwarting (Basalganglia Functions and Dysfunctions), Philipps University Marburg, Marburg.


Huang J, Ulke C, Sander C, Jawinski P, Spada J, Hegerl U, Hensch T (in press). Impact of brain arousal and time-on-task on autonomic nervous system activity in the wake-sleep transition BMC Neuroscience.

Jawinski P, Kirsten H, Sander C, Spada J, Ulke C, Huang J, Burkhardt R, Scholz M, Hensch T & Hegerl U (in press). Human brain arousal in the resting state: A genome-wide association study. Molecular Psychiatry.

Huang J*, Hensch T* (*equally contributing), Ulke C, Sander C, Spada J, Jawinski P & Hegerl U (2017) Evoked potentials and behavioral performance during different states of brain arousal. BMC Neurosci 18: 21.

Hegerl U & Hensch T (2017) Why do stimulants not work in typical depression? Aust N Z J Psychiatry 51: 20-22.

Ulke C*, Huang J* (*equally contributing), Schwabedal JTC, Surova G, Mergl R & Hensch T (2017) Coupling and dynamics of cortical and autonomic signals are linked to central inhibition during the wake-sleep transition. Sci Rep 7: 11804.

Ulke C, Sander C, Jawinski P, Mauche N, Huang J, Spada J, Wittekind D, Mergl R, Luck T, Riedel-Heller S, Hensch T & Hegerl U (2017) Sleep disturbances and upregulation of brain arousal during daytime in depressed versus non-depressed elderly subjects. World J Biol Psychiatry 18: 633-640.

Hegerl U, Sander C, Ulke C, Böttger D, Hensch T, Huang J, Mauche N & Olbrich S (2017) Vigilance Algorithm Leipzig (VIGALL) Version 2.1 - Manual Updated Version, http://research.uni-leipzig.de/vigall/

Nathan PJ, Lim YY, Abbott R, Galluzzi S, Marizzoni M, Babiloni C, Albani D, Bartres-Faz D, Didic M, Farotti L, Parnetti L, Salvadori N, et al. (2017) Association between CSF biomarkers, hippocampal volume and cognitive function in patients with amnestic mild cognitive impairment (MCI). Neurobiol Aging 53: 1-10.

Jawinski P*, Kittel J* (*equally contributing), Sander C, Huang J, Spada J, Ulke C, Wirkner K, Hensch T & Hegerl U (2017) Recorded and Reported Sleepiness: The Association Between Brain Arousal in Resting State and Subjective Daytime Sleepiness. Sleep 40.

Wittekind DA, Spada J, Gross A, Hensch T, Jawinski P, Ulke C, Sander C & Hegerl U (2016) Early report on brain arousal regulation in manic vs depressive episodes in bipolar disorder. Bipolar Disord 18: 502-510.

Spada J, Scholz M, Kirsten H, Hensch T, Horn K, Jawinski P, Ulke C, Burkhardt R, Wirkner K, Loeffler M, Hegerl U & Sander C (2016) Genome-wide association analysis of actigraphic sleep phenotypes in the LIFE Adult Study. J Sleep Res 25: 690-701.

Marchitelli R, Minati L, Marizzoni M, Bosch B, Bartres-Faz D, Muller BW, Wiltfang J, Fiedler U, Roccatagliata L, Picco A, Nobili F, Blin O, et al. (2016) Test-retest reliability of the default mode network in a multi-centric fMRI study of healthy elderly: Effects of data-driven physiological noise correction techniques. Hum Brain Mapp 37: 2114-32.

Jovicich J, Minati L, Marizzoni M, Marchitelli R, Sala-Llonch R, Bartres-Faz D, Arnold J, Benninghoff J, Fiedler U, Roccatagliata L, Picco A, Nobili F, et al. (2016) Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: A multicentric resting-state fMRI study. Neuroimage 124: 442-454.

Jawinski P, Tegelkamp S, Sander C, Hantzsch M, Huang J, Mauche N, Scholz M, Spada J, Ulke C, Burkhardt R, Reif A, Hegerl U & Hensch T (2016) Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep. Chronobiol Int 33: 893-905.

Jawinski P, Mauche N, Ulke C, Huang J, Spada J, Enzenbach C, Sander C, Hegerl U & Hensch T (2016) Tobacco use is associated with reduced amplitude and intensity dependence of the cortical auditory evoked N1-P2 component. Psychopharmacology (Berl) 233: 2173-83.

Hegerl U, Sander C & Hensch T (2016) Arousal Regulation in Affective Disorders. In: Frodl T (ed) Systems Neuroscience in Depression. Academic Press, Amsterdam, pp 341-370

Galluzzi S, Marizzoni M, Babiloni C, Albani D, Antelmi L, Bagnoli C, Bartres-Faz D, Cordone S, Didic M, Farotti L, Fiedler U, Forloni G, et al. (2016) Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a 'European ADNI study'. J Intern Med 279: 576-91.

Sander C, Hensch T, Wittekind DA, Bottger D & Hegerl U (2015) Assessment of Wakefulness and Brain Arousal Regulation in Psychiatric Research. Neuropsychobiology 72: 195-205.

Marizzoni M, Antelmi L, Bosch B, Bartres-Faz D, Muller BW, Wiltfang J, Fiedler U, Roccatagliata L, Picco A, Nobili F, Blin O, Bombois S, et al. (2015) Longitudinal reproducibility of automatically segmented hippocampal subfields: A multisite European 3T study on healthy elderly. Hum Brain Mapp 36: 3516-27.

Loeffler M, Engel C, Ahnert P, Alfermann D, Arelin K, Baber R, Beutner F, Binder H, Brahler E, Burkhardt R, Ceglarek U, Enzenbach C, et al. (2015) The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health 15: 691.

Jawinski P, Sander C, Mauche N, Spada J, Huang J, Schmidt A, Hantzsch M, Burkhardt R, Scholz M, Hegerl U & Hensch T (2015) Brain Arousal Regulation in Carriers of Bipolar Disorder Risk Alleles. Neuropsychobiology 72: 65-73.

Huang J, Sander C, Jawinski P, Ulke C, Spada J, Hegerl U & Hensch T (2015) Test-retest reliability of brain arousal regulation as assessed with VIGALL 2.0. Neuropsychiatric Electrophysiology 1: 1-13.

Hensch T, Blume A, Bottger D, Sander C, Niedermeier N & Hegerl U (2015) Yawning in Depression: Worth Looking Into. Pharmacopsychiatry.

Spada J, Sander C, Burkhardt R, Hantzsch M, Mergl R, Scholz M, Hegerl U & Hensch T (2014) Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptide S receptor gene. PLoS One 9: e98789.

Hegerl U, Hensch T, Böttger D & Sander C (2014) VIGALL 2.0 - a BrainVision Analyzer-compatible tool developed by the University of Leipzig for analysis of different functional brain states (vigilance stages) and their regulation during resting states. Brain Products, http://pressrelease.brainproducts.com/vigall/

Hegerl U & Hensch T (2014) The vigilance regulation model of affective disorders and ADHD. Neurosci Biobehav Rev 44: 45-57.

Geissler J, Romanos M, Hegerl U & Hensch T (2014) Hyperactivity and sensation seeking as autoregulatory attempts to stabilize brain arousal in ADHD and mania? Atten Defic Hyperact Disord 6: 159-73.

Jovicich J, Marizzoni M, Sala-Llonch R, Bosch B, Bartres-Faz D, Arnold J, Benninghoff J, Wiltfang J, Roccatagliata L, Nobili F, Hensch T, Trankner A, et al. (2013) Brain morphometry reproducibility in multi-center 3T MRI studies: a comparison of cross-sectional and longitudinal segmentations. Neuroimage 83: 472-84.

Hensch T (2013) Bedeutung des Neurocan-Gens für manische Symptomatik. Info Neurologie & Psychiatrie 15: 24-25.

Anderson-Schmidt H, Adler L, Aly C, Anghelescu IG, Bauer M, Baumgartner J, Becker J, Bianco R, Becker T, Bitter C, Bonsch D, Buckow K, et al. (2013) The "DGPPN-Cohort": A national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients. Eur Arch Psychiatry Clin Neurosci 263: 695-701.

Pogarell O, Hensch T & Hegerl U (2011) Elektroenzephalographie in der Psychopharmakotherapie. In: Gründer G, Benkert O (eds) Handbuch der psychiatrischen Pharmakotherapie Springer, Heidelberg, pp 399-416

Hensch T & Strobel A (2011) Differentiellpsychologische Aspekte und ihr Nutzen für die Klinische Psychologie. In: Wittchen HU, hoyer J (eds) Klinische Psychologie und Psychotherapie. Springer, Berlin, Heidelberg, pp 169-191

Hensch T, Himmerich H & Hegerl U (2011) ADHD and bipolar disorder: common causes common cure? JAttenDisord 15: 99-100.

Hegerl U, Hensch T & Mulert C (2011) Neurophysiologische Grundlagen psychischer Erkrankungen. In: Möller HJ, Laux G, Kapfhammer HP (eds) Psychiatrie und Psychotherapie, Band 1: Allgemeine Psychiatrie. Springer, Heidelberg, pp 277-292

Drago V, Babiloni C, Bartres-Faz D, Caroli A, Bosch B, Hensch T, Didic M, Klafki HW, Pievani M, Jovicich J, Venturi L, Spitzer P, et al. (2011) Disease tracking markers for Alzheimer's disease at the prodromal (MCI) stage. J Alzheimers Dis 26 Suppl 3: 159-99.

Hensch T, Himmerich H, Hegerl U & McIntyre RS (2010) Stimulants in bipolar disorder: beyond common beliefs. CNSSpectr 15: 469-470.

Hegerl U, Himmerich H, Engmann B & Hensch T (2010) Mania and attention-deficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment? CurrOpinPsychiatry 23: 1-7.

Hegerl U, Hensch T & Himmerich H (2010) Vigilanzregulationsstörungen als pathogenetischer Faktor bei ADHS und Manie. Neuro aktuell 190: 33-35.

Hensch T (2009) Intensity Dependence of Auditory-Evoked Potentials and Serotonergic Neurotransmission: Associations from Genes to Behavior

Bräuer D, Strobel A, Hensch T, Diers K, Lesch KP & Brocke B (2009) Genetic variation of serotonin receptor function affects prepulse inhibition of the startle. JNeural Transm 116: 607-613.

Armbruster D, Moser DA, Strobel A, Hensch T, Kirschbaum C, Lesch KP & Brocke B (2009) Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety. IntJNeuropsychopharmacol 12: 393-401.

Hensch T, Wargelius HL, Herold U, Strobel A, Oreland L & Brocke B (2008) Electrophysiological and behavioral correlates of polymorphisms in the transcription factor AP-2beta coding gene. NeurosciLett 436: 67-71.

Hensch T, Herold U, Diers K, Armbruster D & Brocke B (2008) Reliability of intensity dependence of auditory-evoked potentials. ClinNeurophysiol 119: 224-236.

Müller J, Dreisbach G, Goschke T, Hensch T, Lesch KP & Brocke B (2007) Dopamine and cognitive control: the prospect of monetary gains influences the balance between flexibility and stability in a set-shifting paradigm. EurJNeurosci 26: 3661-3668.

Hensch T, Herold U & Brocke B (2007) An electrophysiological endophenotype of hypomanic and hyperthymic personality. JAffectDisord 101: 13-26.

Hensch T, Wargelius HL, Herold U, Lesch KP, Oreland L & Brocke B (2006) Further evidence for an association of 5-HTTLPR with intensity dependence of auditory-evoked potentials. Neuropsychopharmacology 31: 2047-2054.

Hensch T (2006) Differentiellpsychologische Grundlagen der Klinischen Psychologie. In: Wittchen HU, Hoyer J (eds) Klinische Psychologie und Psychotherapie. Springer, Berlin, pp 145-164

Brocke B, Armbruster D, Muller J, Hensch T, Jacob CP, Lesch KP, Kirschbaum C & Strobel A (2006) Serotonin transporter gene variation impacts innate fear processing: Acoustic startle response and emotional startle. MolPsychiatry 11: 1106-1112.

Letzte Änderung: 29.05.2018, 11:59 Uhr
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Klinik und Poliklinik für Psychiatrie und Psychotherapie