Klinik und Poliklinik für Psychiatrie und Psychotherapie
 Universitätsmedizin Leipzig

Dr. rer. nat. Tilman Hensch

Senior scientist
Telefon 0341-97 24 587
Telefax 0341-97 24 539
E-Mail tilman.hensch@medizin.uni-leipzig.de


  • Since 12/2008: Senior scientist, Neurobiology Research, Department of Psychiatry and Psychotherapy, University of Leipzig, Leipzig.
  • 2002-2008: Research associate, working group Neurogenetics and Individual Differences (Prof. Brocke), Institute of Clinical, Diagnostic and Differential Psychology, University of Technology - TU Dresden, Dresden.
  • 2000-2001: Research associate, working group Prof. Schwarting (Basalganglia Functions and Dysfunctions), Philipps University Marburg, Marburg.


Huang J*; Hensch T* (*equally contributing), Ulke C, Sander C, Spada J, Jawinski P, Hegerl U (in press). Evoked potentials and behavioral performance during different states of brain arousal BMC Neuroscience doi : 10.1186/s12868-017-0340-9.

Nathan PJ, Lim YY, et al. (in press) Association between CSF Biomarkers, Hippocampal Volume and Cognitive Function in Patients with Amnestic Mild Cognitive Impairment (MCI), Neurobiology of Aging, doi: 10.1016/j.neurobiolaging.2017.01.013.

Hegerl U & Hensch T (in press) Why do stimulants not work in typical depression? Australian and New Zealand Journal of Psychiatry. doi: 10.1177/0004867416676369.

Wittekind DA, Spada J, Groß A, Hensch T, Jawinski P, Ulke C, Sander C, Hegerl U (2016) Early report on brain arousal regulation in manic versus depressive episodes in bipolar disorder. Bipolar Disorders 18(6):502-510

Ulke C, Sander C, Jawinski P, Mauche N, Huang J, Spada J, Wittekind D, Mergl R, Luck T, Riedel-Heller S, Hensch T, Hegerl U (in press) Sleep disturbances and upregulation of brain arousal during daytime in depressed versus non-depressed elderly subjects. The World Journal of Biological Psychiatry:1-21. doi: 10.1080/15622975.2016.1224924.

Hegerl U, Sander C, Ulke C, Böttger D, Hensch T, Huang J, Mauche N, Olbrich S (2016). Vigilance Algorithm Leipzig (VIGALL) Version 2.1 - Manual. Available at: http://research.uni-leipzig.de/vigall/.

Jawinski P, Tegelkamp S, Sander C, Häntzsch M, Huang J, Mauche N, Scholz M, Spada J, Ulke C, Burkhardt R, Reif A, Hegerl U, Hensch T (in press). Time to wake up: No impact of COMT Val158Met gene variation on circadian preferences, arousal regulation and sleep. Chronobiology International

Spada J, Scholz M, Kirsten H, Hensch T, Horn K, Jawinski P, Ulke C, Burkhardt R, Wirkner K, Loeffler M, Hegerl U, Sander C (in press) Genome-wide association study of actigraphic sleep phenotypes in the LIFE-Adult-Study. Journal of Sleep Research. doi: 10.1111/jsr.12421

Galluzzi S et al. (in press) Clinical and biomarker profiling of prodromal Alzheimer's disease in workpackage 5 of the Innovative Medicines Initiative PharmaCog project: a 'European ADNI study' Journal of Internal Medicine. doi: 10.1111/joim.12482

Jawinski P, Mauche N, Ulke C, Huang J; Spada J, Enzenbach C; Sander C; Hegerl U & Hensch T (in press) Tobacco use is associated with reduced amplitude and intensity dependence of the cortical auditory evoked N1-P2 component. Psychopharmacology

Sander C, Hensch T, Wittekind DA, Böttger D & Hegerl U. Assessment of Wakefulness and Brain Arousal Regulation in Psychiatric Research. Neuropsychobiology. 2015;72(3-4):195-205. doi: 10.1159/000439384. Epub 2016 Feb 23.

Marchitelli R et al. (in press).Test-Retest Reliability of the Default Mode Network in a Multi-centric fMRI Study of Healthy Elderly: Effects of Data-Driven Physiological Noise Correction Techniques. Human Brain Mapping.

Hegerl U, Sander C, Hensch T (2016). Arousal regulation in affective disorders. In: T Frodl (Hrsg.) Systems Neuroscience in Depression (p. 341 - 370) Elsevier Verlag. http://dx.doi.org/10.1016/B978-0-12-802456-0.00012-1.

Jovicich J, Minati L et al. (2016). Longitudinal reproducibility of default-mode network connectivity in healthy elderly participants: a multicentric resting-state fMRI study. NeuroImage 124(Pt A):442-54. doi: 10.1016/j.neuroimage.2015.07.010. Epub 2015 Jul 9.

Huang J, Sander C, Jawinski P, Ulke C, Spada J, Hegerl U & Hensch T (2015). Test-retest reliability of brain arousal regulation as assessed with VIGALL 2.0. Neuropsychiatric Electrophysiology 1:13; DOI 10.1186/s40810-015-0013-9.

Jawinski P, Sander C, Mauche N, Spada J, Huang J, Schmidt A, Häntzsch M, Burkhardt R, Scholz M, Hegerl U, Hensch T (2015). Brain arousal regulation in carriers of bipolar disorder risk alleles. Neuropsychobiology 72(2):65-73. doi: 10.1159/000437438.

Loeffler M, Engel C et al. (2015). The LIFE-Adult-Study: objectives and design of a population-based cohort study with 10,000 deeply phenotyped adults in Germany. BMC Public Health 15:691. doi: 10.1186/s12889-015-1983-z.

Marizzoni M et al. (2015). Longitudinal Reproducibility of Automatically Segmented Hippocampal Subfields: A Multisite European 3T Study on Healthy Elderly. Human Brain Mapping 36(9):3516-27. doi: 10.1002/hbm.22859.

Hensch T, Blume A, Böttger D, Sander C, Niedermeier N & Hegerl U (2015). Yawning in Depression: Worth Looking Into. Pharmacopsychiatry. doi: 10.1055/s-0035-1545332

Hegerl U, Hensch T, Böttger D & Sander C (2014). VIGALL 2.0: Analyzing different functional brain states and their regulation during resting states. Brain Products Press Release October 9, 2014. http://pressrelease.brainproducts.com/vigall/

Geissler J, Romanos M, Hegerl U &Hensch T (2014). Hyperactivity and sensation seeking as autoregulatory attempts to stabilize brain arousal in ADHD and mania? ADHD Attention Deficit and Hyperactivity Disorders 6, 159-173.

Hegerl U & Hensch T (2014). The vigilance regulation model of affective disorders and ADHD. Neuroscience & Biobehavioral Reviews 44, 45-57.

Spada J, Sander C, Burkhardt R, Häntzsch M, Mergl R, Scholz M, Hegerl U & Hensch T (2014). Genetic association of objective sleep phenotypes with a functional polymorphism in the neuropeptides receptor gene. PLOS ONE 9(6):e98789.

Anderson-Schmidt H et al.(2013). The "DGPPN-Cohort": a national collaboration initiative by the German Association for Psychiatry and Psychotherapy (DGPPN) for establishing a large-scale cohort of psychiatric patients. Eur Arch Psychiatry Clin Neurosci 263, 695-701.

Jovicich J et al. (the Pharmacog Consortium) (2013). Brain morphometry reproducibility in multi-center 3T MRI studies: A comparison of cross-sectional and longitudinal segmentations. Neuroimage 83, 472-484

Hensch T (2013) Bedeutung des Neurocan-Gens für manische Symptomatik. Info Neurologie & Psychiatrie 15, 24-25.

Drago V, Babiloni C, Bartrés-Faz D, Caroli A, Bosch B, Hensch T, Didic M, Klafki HW, Pievani M, Jovicich J, Venturi L, Spitzer P, Vecchio F, Schoenknecht P, Wiltfang J, Redolfi A, Forloni G, Blin O, Irving E, Davis C, Hårdemark HG, Frisoni GB (2011). Disease Tracking Markers for Alzheimer's Disease at the Prodromal (MCI) Stage. Journal of Alzheimer's Disease 26, 159-199.

Hegerl U, Hensch T, Mulert C (2011). Neurophysiologische Grundlagen psychischer Erkrankungen, 4. Aufl. In HJ Möller, G Laux & HP Kapfhammer (Hrsg.), Psychiatrie und Psychotherapie, Band 1: Allgemeine Psychiatrie (S. 277-292). Heidelberg: Springer.

Hensch T, Himmerich H, Hegerl U (2011). Attention Deficit Hyperactivity Disorder and Bipolar Disorder: Common causes common cure? Journal of Attention Disorders 15, 99-100.

Hensch T & Strobel A (2011). Differentiellpsychologische Aspekte und ihr Nutzen für die Klinische Psychologie. In HU Wittchen & J Hoyer (Hrsg.), Klinische Psychologie und Psychotherapie (S. 169-191). Heidelberg: Springer.

Pogarell O, Hensch T & Hegerl U (2011). Elektroenzephalographie in der Psychopharmakotherapie. In G Gründer & O Benkert (Hrsg.), Handbuch der psychiatrischen Pharmakotherapie (S. 399-416). Heidelberg: Springer.

Hegerl U, Hensch T & Himmerich H (2010). Vigilanzregulationsstörungen als pathogenetischer Faktor bei ADHS und Manie. Neuro aktuell 190, 33-35.

Hegerl U, Himmerich H, Engmann B, Hensch T. (2010). Mania and attention-deficit/hyperactivity disorder: common symptomatology, common pathophysiology and common treatment? Current Opinion in Psychiatry 23, 1-7.

Hensch T, Himmerich H, Hegerl U (2010). Stimulants in Bipolar Disorder: Beyond Common Beliefs. CNS Spectrums 15, 469-470.

Armbruster D, Moser DA, Strobel A, Hensch T, Kirschbaum C, Lesch KP & Brocke B (2009). Serotonin transporter gene variation and stressful life events impact processing of fear and anxiety. International Journal of Neuropsychopharmacology 12, 393-401.

Bräuer D, Strobel A, Hensch T, Diers K, Lesch KP & Brocke B (2009) Genetic variation of serotonin receptor function affects prepulse inhibitition of the startle. J Neural Transm. 116, 607-13.

Hensch, T. (2009). Intensity Dependence of Auditory-Evoked Potentials and Serotonergic Neurotransmission: Associations from Genes to Behavior. PhD Thesis, University of Technology, TU Dresden, Dresden.

Hensch T, Herold U, Diers K, Armbruster D & Brocke B (2008). Reliability of intensity dependence of auditory-evoked potentials. Clinical Neurophysiology 119, 224-36.

Hensch T, Wargelius HL, Herold U, Strobel A, Oreland L & Brocke B (2008). Electrophysiological and behavioral correlates of polymorphisms in the transcription factor AP-2beta coding gene. Neuroscience Letters 436, 67-71.

Hensch T, Herold U & Brocke B (2007). An Electrophysiological Endophenotype of Hypomanic and Hyperthymic Personality. Journal of Affective Disorders 101, 13-26.

Müller J, Dreisbach G, Goschke T, Hensch T, Lesch KP & Brocke B (2007). Dopamine and cognitive control: The prospect of monetary gains influences the balance between flexibility and stability in a set-shifting paradigm. The European Journal of Neuroscience 26, 3661-8.

Brocke B, Armbruster D, Müller J, Hensch T, Jacob, CP, Lesch KP, Kirschbaum C & Strobel A (2006). Serotonin transporter gene variation impacts innate fear processing: acoustic startle response and emotional startle. Molecular Psychiatry 11, 1106-12.

Hensch T (2006). Differentiellpsychologische Grundlagen der Klinischen Psychologie. In: HU Wittchen & J Hoyer (Hrsg.), Klinische Psychologie und Psychotherapie (S. 145-162). Heidelberg: Springer.

Hensch T, Wargelius HL, Herold U, Lesch KP, Oreland L & Brocke B (2006). Further evidence for an association of 5-HTTLPR with intensity dependence of auditory evoked potentials. Neuropsychopharmacology 31, 2047-54.

Letzte Änderung: 01.02.2017, 13:21 Uhr
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Klinik und Poliklinik für Psychiatrie und Psychotherapie